| Original Article : The Impact of Serum Uric Acid Level on the Progression of IgA Nephropathy |
| Ho Jun Chin, M.D.1, Ki Young Na, M.D., Ph.D1, 2, Hae Il Cheong, M.D., Ph.D3,Yon-Su Kim, M.D., Ph.D1, 2, Suhnggwon Kim, M.D., Ph.D1, 2 and Dong-Wan Chae, M.D., PhD1, 2 |
Department of Internal Medicine1
Seoul National University Bundang Hospital Department of Internal Medicine2
Seoul National University College of Medicine Department of Pediatrics3
Seoul National University College of Medicine |
| 임상연구 : 혈중 요산 농도가 IgA 신병증의 진행에 미치는 연구 |
| 진호준1 |
| 분당서울대학교병원 내과1, 서울대학교 의과대학 내과학교실2, 서울대학교 의과대학 소아과학교실3 |
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| Abstract |
Purpose
Many evidences about hyperuricemia as a risk factor to hypertension and renal progression in kidney diseases have been reported. We have analyzed the impact of uric acid on renal progression of IgA nephropathy while getting rid of possible confounding variables and revealed the possible pathophysiology of uric acid in terms of hypertension or renal vasculopathy provoked by uric acid.
Methods
We selected 172 patients with IgA nephropathy diagnosed by renal biopsy at Seoul National University Hospital. We adapted the criteria of renal progression as the final value of serum creatinine increased more then twice compared to the value at renal biopsy.
Results
Serum uric acid was correlated with the severity of interstitial fibrosis and tubular atrophy and the presence of artherosclerosis.
The incidence of hypertension during follow-up period was not different between low uric acid group and high uric acid group.
The high uric acid level was an independent risk factor to renal progression in IgA nephropathy with multivariate analysis regardless of the presence of hypertension or artherosclerosis of renal pathologic finding. The high uric acid level was also a risk factor to renal progression in patients with estimated GFR more than 60mL/min/1.73m2.
Conclusion
Serum uric acid was related to the presence of artherosclerosis and the renal progression of IgA nephropathy.
Key Words : Uric acid, Hypertension, IgA nephropathy |
| Key Words:
Uric acid, Hypertension, IgA nephropathy |
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